​Ishikawa NTCC®人源子宫内膜癌细胞human endometrial adenocarcinoma cell line-表达雌激素和孕激素受体,可成瘤 BioVector NTCC保藏中心

Ishikawa NTCC®人源子宫内膜癌细胞human endometrial adenocarcinoma cell line-表达雌激素和孕激素受体,可成瘤

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心

The Ishikawa cell line is a human endometrial adenocarcinoma cell line. It was established from a 39-year-old woman with endometrial adenocarcinoma.

Ishikawa cell line

Key characteristics:

• Origin: Endometrial adenocarcinoma

• Growth pattern: Mosaic-like monolayer growth pattern, often forming piles

• Hormone receptors: Expresses estrogen and progesterone receptors

• Tumorigenicity: Can induce tumors in athymic nude mice

• Applications:

  • Research on endometrial cancer

  • Studies on hormone regulation

  • Drug development and screening

  • Investigation of cellular mechanisms

  
  

Applications in research:

The Ishikawa cell line has been widely used in various research areas, including:

• Endometrial cancer research: Studying the molecular mechanisms of endometrial cancer development and progression.

• Hormone regulation: Investigating the effects of estrogen and progesterone on endometrial cell proliferation and differentiation.

• Drug development and screening: Evaluating the efficacy and toxicity of potential anticancer drugs.

• Cellular mechanisms: Investigating cellular processes such as apoptosis, cell cycle regulation, and signal transduction pathways.

Limitations:

• Immortalized cell line: May not perfectly reflect the behavior of primary tumor cells.

• Potential for genetic drift: Prolonged culture can lead to changes in the cell line's genetic makeup.

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