BioVector® Retatrutide (LY3437943) 瑞他鲁肽三重激动剂研究级多肽 / BioVector® Retatrutide (LY3437943) Research-Grade Peptide

通用定义 / General Definition:

BioVector® Retatrutide 瑞他鲁肽是一种创新的、针对三种不同受体的人源性多肽类候选药物。它被称为**“三重激动剂” (Triple Agonist)，能同时激活：葡萄糖依赖性促胰岛素多肽 (GIP) 受体、胰高血糖素样肽-1 (GLP-1) 受体和胰高血糖素 (Glucagon)** 受体。这种“三靶点”设计旨在通过协同作用，在调节血糖平衡的同时，产生更显著的减重效果并改善非酒精性脂肪性肝病 (NAFLD)。它是继单激动剂（如利拉鲁肽）和双激动剂（如替尔泊肽）之后的最新一代代谢性疾病研究工具。

BioVector® Retatrutide is an innovative, human-derived polypeptide candidate targeting three distinct receptors. Known as a "Triple Agonist," it simultaneously activates the Glucose-dependent Insulinotropic Polypeptide (GIP) receptor, the Glucagon-Like Peptide-1 (GLP-1) receptor, and the Glucagon receptor. This "tri-target" design is engineered to act synergistically, regulating glucose homeostasis while achieving more profound weight loss and improving non-alcoholic fatty liver disease (NAFLD). It represents the latest generation of metabolic disease research tools, following single agonists (e.g., Liraglutide) and dual agonists (e.g., Tirzepatide).

BioVector® Retatrutide 技术规格书 (Technical Specifications)

中文版说明书 (Chinese Datasheet)

1. 基本信息

• 产品名称： Retatrutide (LY3437943)

• 分子式：$C_{221}H_{342}N_{46}O_{68}$

• 序列特征： 含有 39 个氨基酸残基的多肽，其侧链经过脂肪酸修饰以延长体内半衰期。

• 作用机制： 三重激动作用。通过 GLP-1 和 GIP 受体促进胰岛素分泌并抑制食欲；通过胰高血糖素受体增加能量消耗并加速脂肪分解。

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2. 体外实验应用

• 受体活化分析： 在稳定表达 GIPR、GLP-1R 或 GCGR 的 HEK293 细胞系中测定 cAMP 信号通路的激活能力。

• 代谢途径研究： 在原代肝细胞中研究 Retatrutide 对脂质代谢相关基因表达的影响。

• 胰岛生物学： 研究其对分离的胰岛 $\beta$ 细胞分泌胰岛素的刺激作用。

3. 建议储存条件

• 冻干粉： 储存于 -20°C 或 -80°C，避光干燥，可稳定保存 24 个月。

• 溶液态： 溶解于生理盐水或 PBS 后，建议 4°C 保存并在 7 天内使用，严禁反复冻融。

4. 实验注意事项

• 浓度控制： 实验中需使用极低浓度（nM 级别）进行初步测试，因其受体亲和力极高。

• 安全性限制： 本产品仅供实验室科研使用，严禁用于人体。

English Datasheet

1. General Product Information

• Product Name: Retatrutide (LY3437943)

• Molecular Formula:$C_{221}H_{342}N_{46}O_{68}$

• Sequence Characteristics: A 39-amino acid peptide with a fatty acid side-chain modification to enhance its plasma half-life.

• Mechanism of Action: Triple Agonism. It leverages GLP-1 and GIP receptors to stimulate insulin secretion and suppress appetite, while utilizing the Glucagon receptor to increase energy expenditure and facilitate lipolysis.

2. In Vitro Applications

• Receptor Activation Assays: Measuring cAMP signaling potency in HEK293 cell lines stably expressing human GIPR, GLP-1R, or GCGR.

• Metabolic Pathway Analysis: Investigating the effects of Retatrutide on lipid metabolism gene expression in primary hepatocytes.

• Islet Biology: Studying its capacity to stimulate insulin secretion in isolated pancreatic $\beta$-cells.

3. Recommended Storage

• Lyophilized Powder: Store at -20°C or -80°C under desiccated, dark conditions. Stable for up to 24 months.

• Reconstituted Solution: After dissolution in saline or PBS, store at 4°C and use within 7 days. Avoid repeated freeze-thaw cycles.

4. Key Usage Notes

• Potency Management: Due to its exceptionally high receptor affinity, initial testing should be performed at picomolar (pM) to nanomolar (nM) concentrations.

• Usage Restriction: This product is provided strictly for laboratory research purposes only and is not for human use.

注意 / Note: BioVector® Retatrutide 的“三重激动”特性使其在肥胖和糖尿病动物模型（如 ob/ob 小鼠或 DIO 小鼠）中表现出优于双激动剂的代谢改善能力。在进行比较研究时，建议设置单靶点和双靶点激动剂作为平行对照。

The "triple agonist" profile of BioVector® Retatrutide demonstrates superior metabolic improvement in obese and diabetic animal models (e.g., ob/ob or DIO mice) compared to dual agonists. In comparative studies, BioVector® recommends including single-target and dual-target agonists as parallel controls.

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