ND50040 BioVector® Cell Line人诱导多能干细胞系-来源于患有家族性神经退行性疾病的供体

Product Name / 产品名称:
BioVector® ND50040 Cell Line
BioVector® ND50040细胞系

Description / 描述:
The BioVector® ND50040 cell line is a well-characterized human induced pluripotent stem cell (iPSC) line derived from a subject with a familial neurodegenerative disorder. This line is part of the NINDS Human Cell and Data Repository and is specifically related to studies of neurological diseases.
BioVector® ND50040 细胞系是一种特性明确的人诱导多能干细胞系，来源于患有家族性神经退行性疾病的供体。该细胞系是NINDS人类细胞和数据库的一部分，专门用于神经系统疾病的研究。

Repository Information / 库信息:
This collection was formerly maintained at the Coriell Repository and is now maintained at the NINDS Human Cell and Data Repository.
该细胞库原由Coriell维护，现由NINDS人类细胞和数据库维护。

Species / 物种:
Human / 人

Cell Type / 细胞类型:
Induced Pluripotent Stem Cell (iPSC) / 诱导多能干细胞

Disease Association / 疾病关联:
Familial neurodegenerative disorder / 家族性神经退行性疾病

Key Applications / 主要应用:

• Neurodegenerative disease modeling (Parkinson's disease, α-synucleinopathies) / 神经退行性疾病建模（帕金森病、α-突触核蛋白病）

• Blood-brain barrier function studies / 血脑屏障功能研究

• Drug screening and toxicity testing / 药物筛选及毒性测试

• Mechanistic studies of α-synuclein regulation / α-突触核蛋白调控机制研究

Key Research Findings / 关键研究发现:
This cell line has been used in several high-impact studies:
该细胞系已被用于多项高影响力研究：

• DCLK1 Regulates α-Synuclein: ND50040 was used to demonstrate that Doublecortin-like Kinase 1 (DCLK1) regulates α-synuclein levels and toxicity, providing insights into potential therapeutic targets for Parkinson's disease and related disorders.

• DCLK1调控α-突触核蛋白：利用ND50040证明双皮质素样激酶1调控α-突触核蛋白水平和毒性，为帕金森病及相关疾病的潜在治疗靶点提供了见解。

• Lentiviral Approaches for α-Synuclein: This line has been utilized in studies developing lentiviral vectors expressing chimeric NEDD4 ubiquitin ligases as an innovative approach for interfering with α-synuclein accumulation.

• α-突触核蛋白的慢病毒研究方法：该细胞系已被用于开发表达嵌合NEDD4泛素连接酶的慢病毒载体，作为干扰α-突触核蛋白积聚的创新方法。

• Blood-Brain Barrier Function: ND50040 has been employed in iPSC-based models to study the role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function.

• 血脑屏障功能：ND50040已被用于基于iPSC的模型，研究家族性神经退行性疾病相关突变对血脑屏障功能的影响。

Related Cell Lines / 相关细胞系:

Quality Control / 质量控制:
As part of the NINDS Human Cell and Data Repository, this line has been rigorously characterized and quality-controlled for pluripotency, karyotypic stability, and sterility.
作为NINDS人类细胞和数据库的一部分，该细胞系经过严格的特性和质量控制，确保其多能性、核型稳定性和无菌性。

Storage / 存储:

• BioVector® Cryopreservation Medium is recommended for long-term storage in liquid nitrogen vapor phase.

• 推荐使用 BioVector® 细胞冻存液 进行长期保存。

Citation / 引用:
When using this cell line, please cite the following publications as appropriate:
使用此细胞系时，请根据情况引用以下文献：

Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity. J Neurosci. 2020 Jan 8;40(2):291-304.

Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation. Cells. 2021 Nov 21;10(11):3256.

The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids Barriers CNS. 2019 Jul 15;16(1):20.

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