MUTU-I BioVector®人伯基特淋巴瘤细胞株 Human Burkitt Lymphoma Cell Line
- 价 格：¥99850
- 货 号：BioVector®-MUTU-I cell
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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BioVector® MUTU-I 细胞系是研究 EB 病毒 (EBV) 潜伏期调控及 伯基特淋巴瘤 (Burkitt Lymphoma) 的关键模型，因其保留了最接近原始肿瘤的 I 型潜伏期表达模式而备受学术界关注。
| 参数 | 详细信息 |
|---|---|
| 细胞名称 | MUTU-I (或 Mutu I) |
| 物种来源 | 人类 (Homo sapiens) |
| 组织/疾病 | 伯基特淋巴瘤 (Burkitt Lymphoma) |
| 细胞形态 | 淋巴母细胞样；圆形，悬浮生长 |
| 生长特性 | 悬浮生长（倾向于单细胞悬浮，有时形成微小簇） |
| 培养基配方 | RPMI-1640 + 10-15% 胎牛血清 (FBS) |
| 培养环境 | 37°C，5% CO₂，恒温恒湿培养 |
| 传代方法 | 维持细胞密度在 0.3–0.8 x 10⁶ 细胞/ml。该系对过高密度较敏感。 |
| EBV 状态 | EBV 阳性；表现为 I 型潜伏期 (Latency I)，仅表达 EBNA1。 |
| 遗传特征 | 携带典型的 t(8;14) 易位，驱动 MYC 基因高表达。 |
| 主要应用 | EB 病毒潜伏期调控研究、从 I 型向 III 型潜伏期漂移的研究、病毒致癌机制。 |
| 生物安全等级 | 2 级 (因含有人类致病病毒 EBV) |
BioVector® MUTU-I Cell Line Datasheet
| Parameter | Information |
|---|---|
| Name | MUTU-I (or Mutu I) |
| Organism | Human (Homo sapiens) |
| Tissue / Disease | Burkitt Lymphoma |
| Morphology | Lymphoblast-like; round cells growing in suspension |
| Growth Mode | Suspension (tends toward single-cell suspension, occasionally small clusters) |
| Culture Medium | RPMI-1640 supplemented with 10-15% Fetal Bovine Serum (FBS) |
| Culture Conditions | 37°C, 5% CO₂, humidified atmosphere |
| Subculturing | Maintain at 0.3–0.8 x 10⁶ cells/ml. Sensitive to overgrowth/high density. |
| EBV Status | EBV Positive; exhibits Latency I pattern (expresses only EBNA1). |
| Genetic Profile | Characterized by the t(8;14) translocation, driving constitutive MYC expression. |
| Applications | Study of EBV latent gene regulation; analysis of phenotypic "drift" from Latency I to III; viral oncogenesis. |
| Biosafety Level | 2 (Due to the presence of EBV) |
Phenotypic Drift: Mutu I cells are highly valuable because they mimic the EBV expression found in biopsy samples. However, they are prone to phenotypic drift during long-term culture, where they may transition into the Latency III pattern (like Mutu-III).
Selective Markers: Often used to study how the virus evades the host immune system by restricting protein expression to only EBNA1.
表型漂移： Mutu I 细胞因其模拟活检样本中的 EBV 表达模式而具有极高价值。但在长期培养过程中易发生表型漂移，自发转变为 III 型潜伏期模式（类似于 Mutu-III）。
选择性标志物： 常用于研究病毒如何通过限制仅表达 EBNA1 蛋白来逃避宿主免疫系统的监视。
Supplier生产厂家:
BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心
BioVector NTCC Inc.
TEL: 400-800-2947
E-mail: biovector@163.com
工作微信/QQ同号: 1843439339
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