SS1幽门螺杆菌悉尼株 1 号NTCC® Helicobacter pylori Sydney Strain 1 BioVector NTCC保藏中心

BioVector® NTCC® SS1幽门螺杆菌悉尼株 1 号NTCC® Helicobacter pylori Sydney Strain 1

SS1 strain" most commonly refers to the Helicobacter pylori Sydney Strain 1, a crucial bacterial strain used in gastroenterology research. It serves as an essential model for studying the processes of gastric infection, inflammation, and potential treatments for H. pylori-induced diseases in a laboratory setting. Description and Characteristics Organism: Helicobacter pylori. Common Name: Sydney Strain 1 (SS1). Origin: This strain was developed from a human clinical isolate (strain 10700) and specifically adapted to consistently and robustly colonize the stomach of mice, making it a highly effective in vivo research tool. Morphology: It is a Gram-negative bacterium with a characteristic spiral or rod shape. Virulence: It is considered virulent, as it is positive for key virulence factors, including CagA (cagA⁺) and VacA (vacA⁺). Drug Sensitivity: The SS1 strain is noted for an unusual susceptibility to low concentrations of the antibiotic metronidazole (MTZ), likely due to its unique genetic makeup requiring inactivation of two specific genes (rdxA and frxA) for resistance. Biosafety Level: Due to its pathogenic nature, it is typically handled under Biosafety Level 2 (BSL-2) containment practices. Culture and Handling Culture Medium: SS1 is usually cultured on specialized Columbia blood agar plates that are enriched with 5% or 10% defibrinated sheep or horse blood. Growth Conditions: Growth requires specific microaerobic conditions, typically an atmosphere composed of 5% oxygen, 10% carbon dioxide, and 85% nitrogen. Temperature: Cultures are incubated at 37°C. Storage: For long-term storage, vials are frozen at -80°C in media containing glycerol (usually 10% glycerol in Columbia medium or Brucella broth). SS1 株系” 通常指代 幽门螺杆菌悉尼株 1 号 (Sydney Strain 1)，这是胃肠病学研究中广泛使用的适应小鼠的细菌株。它是研究幽门螺杆菌引起的胃部疾病（包括发病机制、感染过程以及药物和疫苗治疗策略）的重要模型。 描述和特征 生物体： Helicobacter pylori (幽门螺杆菌)。 常用名称： 悉尼株 1 号 (Sydney Strain 1, SS1)。 来源： 该菌株源自人类临床分离株 (10700 株)，并经过专门适应，能够持续且稳定地定植于小鼠胃部，使其成为高效的体内 (in vivo) 研究工具。 形态： 它是革兰氏阴性菌，具有典型的螺旋形或杆状形态。 毒力： 它被认为具有毒力，因为它对关键的毒力因子呈阳性，包括 CagA (cagA⁺) 和 VacA (vacA⁺)。 药物敏感性： SS1 菌株值得注意的一点是，它对低浓度的甲硝唑 (MTZ) 抗生素具有异常敏感性，这可能是因为其独特的基因构成要求同时使两个特定基因 (rdxA 和 frxA) 失活才能产生耐药性。 生物安全级别： 由于其致病性，通常在生物安全 2 级 (BSL-2) 的操作规范下处理。 培养和操作 培养基： SS1 通常在富含 5% 或 10% 脱纤维绵羊或马血的哥伦比亚血琼脂平板上培养。 生长条件： 生长需要特定的微需氧条件，通常是 5% 氧气、10% 二氧化碳和 85% 氮气的混合气体环境。 温度： 培养物在 37°C 下孵育。 储存： 如需长期储存，将菌株冻存于含甘油的培养基（通常是 10% 甘油的哥伦比亚培养基或布鲁氏肉汤）中，温度为 -80°C。 BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心 电话:400-800-2947 工作QQ/微信同号:1843439339 网址 www.biovector.net

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