TBP-3868小鼠甲状腺乳头状癌PTC研究细胞系NTCC® mouse Papillary Thyroid Carcinoma cell line BioVector NTCC保藏中心

BioVector® NTCC® TBP-3868小鼠甲状腺乳头状癌PTC研究细胞系NTCC® mouse Papillary Thyroid Carcinoma cell line

NTCC® TBP-3868 细胞系是一种鼠源（小鼠）**甲状腺乳头状癌（PTC）**研究细胞系，源自基因工程小鼠模型。它是学术研究中用于在实验室环境中研究晚期甲状腺癌的工具。
一般信息
特性 详情
物种 小鼠（鼠源；B6129F1/J 背景）
组织来源 甲状腺（甲状腺乳头状癌 - PTC）
细胞类型 癌细胞系，上皮样形态

生长方式 贴壁；在培养中作为单层生长，细胞紧密连接
基因型/突变 具有特定的致癌基因谱：BrafV600E/WT 和 p53−/−（p53 缺陷型）
分化程度 在体内分化良好，但具有高级别核特征和侵袭性生长
生物标志物 表达上皮标志物 E-钙粘蛋白 (CDH1)，并且 TTF-1 (NKX2-1) 灶性阳性
培养条件
TBP-3868 细胞系使用标准的哺乳动物细胞培养规范进行培养，如科学文献中所述：
培养基：补充 10% 胎牛血清（FBS）和青霉素/链霉素的 Dulbecco's modified Eagle's medium (DMEM)。
最佳温度：37°C。
CO₂ 浓度：在湿润培养箱中含 5% CO₂。
生长速度：比人类甲状腺癌细胞系生长更快，在大约四天内达到融合。
应用
该细胞系是研究甲状腺癌的重要临床前模型：
甲状腺癌建模：用于生成 PTC 的原位小鼠模型，以在体内研究肿瘤生长和进展。
药物测试：对于测试新型治疗药物和靶向疗法（特别是针对 MAPK 信号通路）的体外和体内功效非常有价值。
基因功能研究：其明确的遗传背景有助于了解 BRAF 和 p53 突变在甲状腺癌发展中的作用。

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心
电话:400-800-2947
工作QQ/微信同号:1843439339
网址 www.biovector.net

The NTCC® TBP-3868 cell line is a murine (mouse) papillary thyroid cancer (PTC) research cell line derived from a genetically engineered mouse model. It is not a commercial product with a standard datasheet but rather a tool used in academic research to study advanced thyroid cancer in a laboratory setting.
General Information
Property  Detail
Species Mouse (Murine; B6129F1/J background)
Tissue of Origin Thyroid (Papillary Thyroid Carcinoma - PTC)
Cell Type Cancer cell line, epithelial-like morphology
Growth Mode Adherent; grows as a monolayer in culture with cells in close association
Genotype/Mutations Carries a specific oncogenic profile: BrafV600E/WT and p53−/− (p53-deficient)
Differentiation Well-differentiated in vivo, but with high-grade nuclear features and aggressive growth
Biomarkers Expresses the epithelial marker E-cadherin (CDH1) and is focally positive for TTF-1 (NKX2-1)
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Culture Conditions
The TBP-3868 cell line is cultured using standard mammalian cell culture practices, as described in scientific literature:
Culture Medium: Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% Fetal Bovine Serum (FBS) and penicillin/streptomycin.
Optimal Temperature: 37°C.
CO₂ Concentration: 5% CO₂ in a humidified incubator.
Growth Rate: Grows faster than human thyroid cancer cell lines, reaching confluence in approximately four days.
Applications
This cell line serves as an important preclinical model for studying thyroid cancer:
Thyroid Cancer Modeling: Used to generate orthotopic mouse models of PTC to study tumor growth and progression in vivo.
Drug Testing: Valuable for testing novel therapeutic agents and targeted therapies, especially those targeting the MAPK signaling pathway, both in vitro and in vivo.
Gene Function Studies: Its defined genetic background makes it useful for understanding the roles of BRAF and p53 mutations in thyroid cancer development.

BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心
电话:400-800-2947
工作QQ/微信同号:1843439339
网址 www.biovector.net