D2SC/1永生化的小鼠脾脏树突状细胞系immortalized mouse dendritic cell line BioVector NTCC典型培养物保藏中心 BioVector NTCC保藏中心
- 价 格：¥99850
- 货 号：BioVector®-D2SC/1
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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BioVector® NTCC® D2SC/1永生化的小鼠脾脏树突状细胞系immortalized mouse dendritic cell line BioVector NTCC典型培养物保藏中心
BioVector® D2SC/1细胞系是一种永生化的小鼠树突状细胞系，从BALB/c小鼠的脾脏中分离而来。它被用作研究树突状细胞生物学的模型，尤其是在免疫学、抗原呈递和免疫治疗领域。
主要特征
来源：该细胞系来源于BALB/c小鼠脾脏中分离出的树突状细胞（DC）。原代细胞通过禽类逆转录病毒MH2的v-Myc癌基因实现永生化。
抗原呈递：D2SC/1细胞表达MHC I类和MHC II类分子，以及协同刺激分子B7-1和B7-2。这使它们能够作为有效的抗原呈递细胞（APC），刺激T细胞反应。
免疫调节研究：该细胞系常用于研究β-葡聚糖或病毒蛋白等不同因素如何调节免疫应答。相关研究包括癌症免疫治疗，研究人员通过基因改造使其呈递肿瘤相关抗原。
培养条件：D2SC/1细胞通常在添加胎牛血清的杜氏改良伊格尔培养基（DMEM）中培养。它们可以作为贴壁单层细胞生长。
研究应用
癌症免疫治疗：用于开发和测试细胞疫苗。例如，一些研究使用D2SC/1细胞与肿瘤细胞的融合杂交体，以产生有效的抗肿瘤免疫应答。
抗原处理：研究树突状细胞如何处理外源性和内源性抗原并将其呈递给T细胞。
炎症信号：研究各种刺激对DC成熟及其后续T细胞激活的影响。
基因改造：该细胞系易于进行基因改造，使研究人员能够探索特定基因在免疫调节中的功能。例如，研究人员创建了一个D2SC/1-CTLA4-Ig变体细胞系，用于研究移植模型中的同种异体移植物存活。
BioVector® D2SC/1 cell line is an immortalized mouse dendritic cell line that was isolated from the spleen of a BALB/c mouse. It is used as a model for studying dendritic cell biology, particularly in the context of immunology, antigen presentation, and immunotherapy.
Key characteristics
Origin: Derived from dendritic cells (DC) isolated from the spleen of a BALB/c mouse. The primary cells were immortalized using the avian retrovirus MH2 v-Myc oncogene.
Antigen presentation: D2SC/1 cells express both MHC Class I and MHC Class II molecules, along with the co-stimulatory molecules B7-1 and B7-2. This allows them to act as potent antigen-presenting cells (APCs) to stimulate T-cell responses.
Immunomodulatory studies: The cell line is frequently used to study how different factors, such as β-glucans or viral proteins, can modulate the immune response. This has included work related to cancer immunotherapy, where they have been genetically modified to present tumor-associated antigens.
Culture conditions: D2SC/1 cells are typically cultured in Dulbecco's modified Eagle medium (DMEM) and supplemented with fetal calf serum. They can grow as an adherent monolayer.
Research applications
Cancer immunotherapy: Used to develop and test cellular vaccines. For instance, studies have used fusion hybrids of D2SC/1 cells with tumor cells to create potent anti-tumor immune responses.
Antigen processing: Investigating how dendritic cells process both exogenous and endogenous antigens for presentation to T-cells.
Inflammatory signaling: Studying the effect of various stimuli on DC maturation and their subsequent activation of T-cells.
Gene modification: The cell line is amenable to genetic modification, allowing researchers to explore the function of specific genes in immune regulation. For example, a variant cell line, D2SC/1-CTLA4-Ig, was created to study allograft survival in transplantation models.
Supplier来源:BioVector NTCC Inc.
Email: biovector@163.com
Website网址: http://www.biovector.net
BioVector® D2SC/1细胞系是一种永生化的小鼠树突状细胞系，从BALB/c小鼠的脾脏中分离而来。它被用作研究树突状细胞生物学的模型，尤其是在免疫学、抗原呈递和免疫治疗领域。
主要特征
来源：该细胞系来源于BALB/c小鼠脾脏中分离出的树突状细胞（DC）。原代细胞通过禽类逆转录病毒MH2的v-Myc癌基因实现永生化。
抗原呈递：D2SC/1细胞表达MHC I类和MHC II类分子，以及协同刺激分子B7-1和B7-2。这使它们能够作为有效的抗原呈递细胞（APC），刺激T细胞反应。
免疫调节研究：该细胞系常用于研究β-葡聚糖或病毒蛋白等不同因素如何调节免疫应答。相关研究包括癌症免疫治疗，研究人员通过基因改造使其呈递肿瘤相关抗原。
培养条件：D2SC/1细胞通常在添加胎牛血清的杜氏改良伊格尔培养基（DMEM）中培养。它们可以作为贴壁单层细胞生长。
研究应用
癌症免疫治疗：用于开发和测试细胞疫苗。例如，一些研究使用D2SC/1细胞与肿瘤细胞的融合杂交体，以产生有效的抗肿瘤免疫应答。
抗原处理：研究树突状细胞如何处理外源性和内源性抗原并将其呈递给T细胞。
炎症信号：研究各种刺激对DC成熟及其后续T细胞激活的影响。
基因改造：该细胞系易于进行基因改造，使研究人员能够探索特定基因在免疫调节中的功能。例如，研究人员创建了一个D2SC/1-CTLA4-Ig变体细胞系，用于研究移植模型中的同种异体移植物存活。
BioVector® D2SC/1 cell line is an immortalized mouse dendritic cell line that was isolated from the spleen of a BALB/c mouse. It is used as a model for studying dendritic cell biology, particularly in the context of immunology, antigen presentation, and immunotherapy.
Key characteristics
Origin: Derived from dendritic cells (DC) isolated from the spleen of a BALB/c mouse. The primary cells were immortalized using the avian retrovirus MH2 v-Myc oncogene.
Antigen presentation: D2SC/1 cells express both MHC Class I and MHC Class II molecules, along with the co-stimulatory molecules B7-1 and B7-2. This allows them to act as potent antigen-presenting cells (APCs) to stimulate T-cell responses.
Immunomodulatory studies: The cell line is frequently used to study how different factors, such as β-glucans or viral proteins, can modulate the immune response. This has included work related to cancer immunotherapy, where they have been genetically modified to present tumor-associated antigens.
Culture conditions: D2SC/1 cells are typically cultured in Dulbecco's modified Eagle medium (DMEM) and supplemented with fetal calf serum. They can grow as an adherent monolayer.
Research applications
Cancer immunotherapy: Used to develop and test cellular vaccines. For instance, studies have used fusion hybrids of D2SC/1 cells with tumor cells to create potent anti-tumor immune responses.
Antigen processing: Investigating how dendritic cells process both exogenous and endogenous antigens for presentation to T-cells.
Inflammatory signaling: Studying the effect of various stimuli on DC maturation and their subsequent activation of T-cells.
Gene modification: The cell line is amenable to genetic modification, allowing researchers to explore the function of specific genes in immune regulation. For example, a variant cell line, D2SC/1-CTLA4-Ig, was created to study allograft survival in transplantation models.
Supplier来源:BioVector NTCC Inc.
Email: biovector@163.com
Website网址: http://www.biovector.net
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