mHypoE-N43/5永生化胚胎小鼠下丘脑神经元细胞BioVector NTCC®典型培养物保藏中心

Key Characteristics

• Origin: Derived from primary hypothalamic cultures of embryonic day 15 (E15) mice.

• Immortalization: Immortalized by retroviral transfer of the Simian virus 40 (SV40) large T antigen.

• Cell Type: Described as a mouse embryonic neuron cell line expressing the Kiss1 gene and proopiomelanocortin (POMC), although it contains multiple types of neural populations found in the developing hypothalamus.

• Sex: The donor sex is female.

• Usage: It serves as a valuable model for research into conditions like obesity, diabetes, and related metabolic disorders, and for investigating cellular responses to various stimuli such as leptin, tunicamycin (ER stress inducer), and non-nutritive sweeteners.

NTCC® mHypoE-N43/5细胞系（也称为N43/5）是一种永生化的胚胎小鼠下丘脑神经元细胞系，用作研究下丘脑功能（特别是能量平衡、新陈代谢和神经内分泌信号传导）的体外模型。

• 起源：源自胚胎第15天（E15）小鼠的初级下丘脑培养物。

• 永生化：通过猿猴病毒40（SV40）大T抗原的逆转录病毒转移实现永生化。

• 细胞类型：被描述为表达Kiss1基因和阿黑皮素原（POMC）的小鼠胚胎神经元细胞系，但它包含发育中的下丘脑中发现的多种类型的神经细胞群。

• 性别：供体性别为雌性。

• 用途：它是研究肥胖症、糖尿病及相关代谢紊乱等病症，以及研究细胞对瘦素、衣霉素（内质网应激诱导剂）和非营养性甜味剂等各种刺激反应的宝贵模型。

BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心

BioVector NTCC Inc.

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