BJAB永生化的人类B细胞株-爱泼斯坦-巴尔病毒 (EBV) 阴性伯基特淋巴瘤细胞BioVector NTCC典型培养物保藏中心

价　　格：¥59960
货　　号：NTCC®-BJAB cell
产　　地：北京

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The NTCC® BJAB cell line is an immortalized human B-cell line derived from a patient with Burkitt lymphoma. It is notable in research because it is one of the few Burkitt lymphoma cell lines that is Epstein-Barr virus (EBV)-negative.

BJAB morphology. BJAB cells at 4 d after being split 1:4 should have a... | Download Scientific Diagram

Key Characteristics

Origin: Established in 1973 from an inguinal tumor of a 5-year-old African girl.
Disease: Burkitt lymphoma, a type of non-Hodgkin B-cell lymphoma.
EBV Status: EBV-negative, which makes it a crucial model for studying lymphoma pathogenesis without the confounding effects of the virus.
Morphology: Cells are round to polymorphic and grow in suspension, singly and in clumps.
Growth Conditions: Typically cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum (FBS).
Immunophenotype: Characterized by the expression of several B-cell surface markers, including CD10+, CD19+, and CD20+.

Research Applications

Due to its specific characteristics, the BJAB cell line is widely used in various research areas:

Lymphoma Research: Investigating the pathophysiology of Burkitt lymphoma and testing therapeutic strategies, particularly those targeting B-cell malignancies.
Virology and Immunology: Used as a model to study B-cell receptor (BCR) signaling, apoptosis mechanisms (such as Fas/CD95-mediated apoptosis), and host interactions with viruses like EBV and KSHV.
Drug Screening: The cell line has been adapted into assays to preclinically screen antisense oligonucleotides (ASOs) for their pro-inflammatory potential, due to high expression of Toll-like receptor 9 (TLR9).
Genetic Studies: It serves as a valuable control for comparing EBV-positive cell lines (such as its EBV-converted subline, GC-BJAB) and understanding virus-related carcinogenic mechanisms.

NTCC® BJAB细胞系是一种永生化的人类B细胞系，源自一名伯基特淋巴瘤 (Burkitt lymphoma) 患者。它在研究中非常重要，因为它是少数爱泼斯坦-巴尔病毒 (EBV) 阴性的伯基特淋巴瘤细胞系之一。

Frontiers | An Engineered Fusion Protein Anti-CD19(Fab)-LDM Effectively Inhibits ADR-Resistant B Cell Lymphoma

主要特点

来源： 1973年建立，取自一名5岁非洲女性患者腹股沟肿瘤组织。
疾病类型：伯基特淋巴瘤，一种非霍奇金B细胞淋巴瘤。
EBV状态：阴性。这使其成为研究淋巴瘤发病机制的重要模型，可以排除病毒的影响。
形态：细胞呈圆形至多形性，在培养基中悬浮生长，形成单个细胞或细胞团块。
培养条件：通常在补充有10%胎牛血清 (FBS) 的RPMI 1640培养基中培养。
免疫表型：表达多种B细胞表面标志物，包括CD10+, CD19+, 和CD20+。

研究应用

BJAB细胞系因其特性而被广泛应用于多个研究领域：

淋巴瘤研究：用于探索伯基特淋巴瘤的病理生理学，并测试针对B细胞恶性肿瘤的治疗策略。
病毒学和免疫学：作为研究B细胞受体 (BCR) 信号通路、细胞凋亡机制（如Fas/CD95介导的凋亡）、NF-κB激活以及宿主与病毒（如EBV和KSHV）之间相互作用的模型。
药物筛选：由于其高表达Toll样受体9 (TLR9)，该细胞系已被用于检测反义寡核苷酸 (ASOs) 的促炎潜力。
遗传学研究：可与EBV阳性的衍生细胞系（例如GC-BJAB）进行比较研究，以了解病毒相关的致癌机制。

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