NTCC™ Eubacterium ramulus 蓝桉真杆菌-BioVector NTCC典型培养物保藏中心

NTCC™ Eubacterium ramulus is a species of strictly anaerobic bacteria that is a common and important member of the human gut microbiota. It is a gram-positive bacterium that was first isolated from human feces. While there isn't a single, universally famous "strain" like some other bacteria, research has focused on several strains, such as the type strain ATCC 29099 (also known as DSM 3995) and other strains like WK1 (DSM 16296).

Key Characteristics and Role in Human Health

The significance of Eubacterium ramulus lies in its metabolic activity, particularly its ability to metabolize dietary compounds that are otherwise indigestible by the human body.

• Flavonoid Degradation: This is the most well-studied function of E. ramulus. It can degrade various types of flavonoids—plant polyphenols found in fruits, vegetables, and tea—into smaller, more easily absorbed metabolites. These metabolites, such as phenolic acids, are believed to contribute to many of the health benefits associated with a high intake of plant-based foods, including antioxidant, anti-inflammatory, and cardioprotective effects.

• Butyrate Production:E. ramulus is also a butyrate-producing bacterium. Butyrate is a short-chain fatty acid (SCFA) that is a primary energy source for the cells lining the colon. It plays a critical role in maintaining gut barrier integrity, reducing inflammation, and potentially protecting against colorectal cancer.

• Symbiotic Relationships: Its ability to degrade flavonoids can be enhanced through a symbiotic relationship with other gut bacteria. For example, some studies show that E. ramulus works with bacteria like Bacteroides thetaiotaomicron, which can break down complex carbohydrates (like starch), providing simpler sugars that E. ramulus can use to fuel its flavonoid degradation and butyrate production.

• Influence on Gut Ecology: The presence of flavonoids in the diet can directly influence the abundance of E. ramulus in the gut, indicating that diet plays a significant role in shaping the gut microbial community.

NTCC™ 蓝桉真杆菌 (Eubacterium ramulus) 菌株

蓝桉真杆菌 (Eubacterium ramulus) 是一种严格厌氧的细菌，是人体肠道菌群中常见且重要的成员。它是一种革兰氏阳性细菌，最初是从人类粪便中分离出来的。尽管没有像其他一些细菌那样单一的、举世闻名的“菌株”，但研究主要集中在一些特定菌株上，例如模式菌株 ATCC 29099（也称 DSM 3995） 和其他菌株如 WK1（DSM 16296）。

主要特性及其在人类健康中的作用

蓝桉真杆菌的重要性在于其代谢活性，特别是它能够代谢人体无法消化的膳食化合物。

• 类黄酮降解: 这是蓝桉真杆菌研究最多的功能。它能将各种类黄酮——存在于水果、蔬菜和茶叶中的植物多酚——降解成更小、更易于吸收的代谢物。这些代谢物，例如酚酸，被认为能带来富含植物性食物的饮食所带来的许多健康益处，包括抗氧化、抗炎和保护心血管的作用。

• 丁酸盐生成: 蓝桉真杆菌也是一种能产生丁酸盐的细菌。丁酸盐是一种短链脂肪酸（SCFA），是结肠内壁细胞的主要能量来源。它在维持肠道屏障完整性、减少炎症以及潜在地预防结直肠癌方面起着关键作用。

• 共生关系: 它降解类黄酮的能力可以通过与肠道中其他细菌的共生关系得到增强。例如，一些研究表明，蓝桉真杆菌可以与**Bacteroides thetaiotaomicron** 等细菌协同工作，后者能分解复杂的碳水化合物（如淀粉），提供蓝桉真杆菌可利用的简单糖分，从而促进其类黄酮降解和丁酸盐生成。

• 对肠道生态的影响: 饮食中的类黄酮可以直接影响肠道中蓝桉真杆菌的数量，这表明饮食在塑造肠道微生物群落方面起着重要作用。

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