NTCC® KILR CD16 Effector Cells稳转CD16的人细胞毒性 t 淋巴细胞-BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心
- 价 格:¥989865
- 货 号:NTCC®97-0007-01
- 产 地:北京
- BioVector NTCC典型培养物保藏中心
- 联系人:Dr.Xu, Biovector NTCC Inc.
电话:400-800-2947 工作QQ:1843439339 (微信同号)
邮件:Biovector@163.com
手机:18901268599
地址:北京
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NTCC® KILR CD16 Effector Cells are purified human cytotoxic T lymphocytes stably expressing CD16 (FcɣRIIIa; V158 variant), produced in a standardized batch. The cells were developed for antibody-dependent cell-mediated cytotoxicity (ADCC) applications where low lot-to-lot variability is required, such as lot release of therapeutic antibodies.
- Receptor Species
- Human
- Cell Type
- Oligoclonal human cytotoxic T lymphocytes
- Assay Measures
- Cellular Cytotoxicity
- Culture Mode
- Suspension
- Storage
Store in vapor phase of liquid N2.
Highlights of KILR CD16 Effector Cells
Eliminate Donor Variability – Primary effector cells (human cytotoxic T lymphocytes) from a single donor engineered to stably express CD16 (V158)
Fit for Long-Term QC Testing – Uniformly manufactured to ensure lot-to-lot consistency and produce high S/B ratios
Measure Target Cell Death – High killing capacity for implementing ADCC or TCR for lot release or characterization
Single Donor-Derived Effector Cells
Single donor-derived cytotoxic T lymphocytes (CTLs) transfected with CD16 (FcγRIIIa-V158). KILR CD16 Effector Cells are engineered to express CD16 receptor to form an immunological synapse between the target antibody and antigen that ultimately triggers the release of perforins, granzymes, and cytokines that promote cell death when delivered to target cell cytosol. A. KILR CD16 Effector Cells showing a polyclonal population of predominantly (>98%) CD8+ cells and (B.) positive for CD3 with robust and stable expression of CD16. C. KILR CD16 Effector Cells have functional CD3 as demonstrated by the ability of cells to stimulate T-cell redirection in the presence of blinatumomab (see the section on T-cell redirection).
Excellent Intermediate Precision of ADCC and High Lot-to-Lot Reproducibility
Evaluation of the intra- and inter-lot performance of KILR CD16 Effector Cells in a Rituximab ADCC model. High lot-to-lot reproducibility ensures long-term support for QC testing.
BioVector NTCC质粒载体菌株细胞蛋白抗体基因保藏中心
www.biovector.net
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