Octanoyltransferase LipM (Staphylococcus aureus subsp. aureus NCTC 8325) protein蛋白 BioVector NTCC质粒载体菌种细胞基因保藏中心

Octanoyltransferase LipM (Staphylococcus aureus subsp. aureus NCTC 8325) protein蛋白

Octanoyltransferase LipM (Staphylococcus aureus subsp. aureus NCTC 8325)
Quantity:100ug
Cat No.: BioVector®-931751

S.aureus synthesizes lipoic acid via de novo biosynthesis using the enzymes LipM- octanoyl transferase; LipA – lipoyl synthethase; and LipL – amidotransferase. During lipoic acid salvage, S. aureus is thought to use two lipoic acid ligases, LplA1 and LplA2. Current evidence suggests LplA1 lipoylates GcvH, while LplA2 lipoylates the GcvH-Like protein, GcvH-L.

Function
function
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.

Miscellaneous
In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. The reaction proceeds via an octanoyl-thioester enzyme intermediate.

Catalytic activity
L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]

Pathway
Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].

PRO ID PR:Q2FY37
PRO name octanoyltransferase LipM (Staphylococcus aureus subsp. aureus NCTC 8325)
Synonyms PRO-short-label: EXACT: lipM (STAA8)
Gene-based: RELATED: SAOUHSC_01629 | lipM
Other: EXACT: octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferase (Staphylococcus aureus subsp. aureus NCTC 8325)

Definition A protein that is a translation product of the lipM gene in Staphylococcus aureus subsp. aureus NCTC 8325. [PRO:DNx, UniProtKB:Q2FY37]
PRO Category organism-gene
Parent PR:000000001 protein
Gene Template EnsemblBacteria:SAOUHSC_01629 lipM
Taxon NCBITaxon:93061 Staphylococcus aureus subsp. aureus NCTC 8325

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