murine TLR5-expressing HEK 293 cells TLR5基因稳转表达细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
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- 货 号:murine TLR5-expressing HEK 293 cells
- 产 地:北京
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murine TLR5-expressing HEK 293 cells TLR5基因稳转表达细胞株
HEK293 clones expressing TLR5
Cat#: BioVector924661
293/TLR5 cells were obtained by stable transfection of HEK293 cells with a pUNO-TLR5 plasmid which expresses the human or murine TLR5 gene.
The control cell line of 293/TLR5 cells is 293/null.
Figures
TLR and NOD induction profile of 293 clonesTLR and NOD induction profile of 293 clones
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Specifications
Antibiotic resistance: blasticidin
Growth medium: DMEM, 4.5 g/l glucose, 2-4 mM L-glutamine, 10% (v/v) fetal bovine serum, 50 U/ml penicillin, 50 μg/ml streptomycin, 100 μg/ml Normocin™
Guaranteed mycoplasma-free
Description
TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria. Activation of the receptor stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88 and the serine kinase IRAK [1, 2]. TLR5 can generate a proinflammatory signal as a homodimer suggesting that it might be the only TLR participating in flagellin recognition [2]. However, TLR5 may require the presence of a co-receptor or adaptor molecule for efficient ligand recognition and/or signaling [3].
1. Gewirtz AT. et al., 2001. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol, 167(4):1882-5
2. Hayashi F. et al., 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature, 410(6832):1099-103
3. Tallant T. et al., 2004. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol. 4(1):33.
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