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pcDNA3-KMT2A plasmid vector质粒载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

  • 价  格:¥59865
  • 货  号:pcDNA3-KMT2A
  • 产  地:北京
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pcDNA3-KMT2A plasmid vector质粒载体

RefSeq NM_005933.4
RefSeq Size 14982 bp
RefSeq ORF 11910 bp
Locus ID 4297
Domains AT_hook, SET, BROMO, PHD, zf-CXXC, PostSET, FYRN, FYRC
Protein Families Druggable Genome
Gene Summary This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

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