YUMMER1.7D5 Mouse Melanoma Cell Line小鼠黑色素瘤细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

YUMMER1.7D5 Mouse Melanoma Cell Line小鼠黑色素瘤细胞株

YUMMER1.7D5 Mouse Melanoma Cell Line: Overview: The YUMMER1.7D5 mouse melanoma cell line is both immunocompetent and reflective of the somatic mutations common in melanomas. YUMMER1.7D5 carries three driver mutations of melanoma: Braf V600E, Pten -/- and Cdkn2
YUMMER1.7D5 mouse melanoma cell line for studies of immune checkpoint inhibition and mechanisms of antitumor responses.

Carries three driver mutations of melanoma:
Braf V600E
Pten -/-
Cdkn2 -/- (1,2)

Harbors a high frequency of stable UV-induced somatic mutations which have shown to stimulate host adaptive immune response
Cells are diploid, allowing for enhanced knockout frequency in CRISPR-based screens
Contains genetically modified organisms (GMO)

Size: ≥ 1 x 106 Cells/Vial

Comments Characteristics: Diploid clone of parent cell line.
Knockout cell: Method=KO mouse; MGI; MGI:104738; Cdkn2a.
Knockout cell: Method=KO mouse; MGI; MGI:109583; Pten.
Transformant: NCIt; C17231; Ultraviolet radiation.
Sequence variations Mutation; MGI; MGI:88190; Braf; Simple; p.Val637Glu (c.1910T>A); Zygosity=Heterozygous (from parent cell line).
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: (YUMMER1.7)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line

Supplier来源:BioVector NTCC Inc.
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