HL-60/ADR人急性白血病阿霉素耐药细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
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HL-60/ADR人急性白血病阿霉素耐药细胞株
Cell line name HL-60/ADRSynonyms HL60/ADR; HL60/Adr; HL60-ADRComments Population: Caucasian.Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).Derived from sampling site: Peripheral blood.Sequence variations Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).Disease Adult acute myeloid leukemia (NCIt: C9154)Acute myeloid leukemia (ORDO: Orphanet_519)Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)Hierarchy Parent: CVCL_0002 (HL-60)Sex of cell FemaleAge at sampling 36YCategory Cancer cell linePublications PubMed=2425939Marsh W., Sicheri D., Center M.S.Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug.Cancer Res. 46:4053-4057(1986)
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Cell line name HL-60/ADRSynonyms HL60/ADR; HL60/Adr; HL60-ADRComments Population: Caucasian.Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).Derived from sampling site: Peripheral blood.Sequence variations Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).Disease Adult acute myeloid leukemia (NCIt: C9154)Acute myeloid leukemia (ORDO: Orphanet_519)Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)Hierarchy Parent: CVCL_0002 (HL-60)Sex of cell FemaleAge at sampling 36YCategory Cancer cell linePublications PubMed=2425939Marsh W., Sicheri D., Center M.S.Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug.Cancer Res. 46:4053-4057(1986)
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