Sigma1278b yeast strain酵母菌株 BioVector NTCC质粒载体菌种细胞基因保藏中心
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- 货 号：Sigma1278b
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Sigma1278b yeast strain酵母菌株
Sigma1278b Genotype: MATα Sigma1278b was first isolated in the lab of Marcelle Grenson in the early 1960s, as described in André B (2018) Tribute to Marcelle Grenson (1925-1996), A Pioneer in the Study of Amino Acid Transport in Yeast. Int J Mol Sci 19(4), PMID:29659503, which contains the complete, exact pedigree of Σ1278b from the Grenson lab archives. A short excerpt: "A new, prototrophic reference strain was thus isolated: strain Σ1278b. It was obtained by first crossing the YFa-derived yeast D77 (auxotrophic for uracil and glutamate) with the yeast 1422-11D that was received from the American geneticist Donald C. Hawthorne. The derived haploid strain Σ15d (Σ stands for “segregant”) was then crossed with strain DP1-1B received from Piotr Slonimski, and one of the spores issued from this cross gave rise to Σ1278b." In September 1970, Grenson sent to Gerry Fink a aap/apf1/shr3 mutant isolated from Σ1278b. This strain, which likely diploidized during successive subculturing, was classified as “Fink lab Foreigner strains, F35”. As detailed in the note provided by the Fink lab, collected Nov. 1998 by Cora Styles, analysis twenty years later of this mutant by C. Gimeno and P. Ljungdahl allowed them to discover pseudohyphal growth : Gimeno, C. J., Ljungdahl, P. O., Styles, C. A., & Fink, G. R. (1992). Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell, 68(6), 1077–1090, PMID:1547504. Thanks to Bruno André for contacting SGD directly to share and disseminate this information. Notes: Used in pseudohyphal growth studies. Detailed notes about the sigma strains have been kindly provided by Cora Styles. Granek and Magwene, PLoS Genet. 2010 Jan 22;6(1):e1000823, established that certain lineages of the Sigma1278B background contain a nonsense mutation in RIM15, a G-to-T transversion at position 1216 that converts a Gly codon to an opal stop codon. This rim15 mutation interacts epistatically with mutations in certain other genes to affect colony morphology. The Sigma1278b genome is closely related to S288c, and shares some other genomic regions with W303 [1]. Annotation of the Sigma1278b genome and information about the systematic deletion collection can be found in Dowell et al. (2010).
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
Sigma1278b Genotype: MATα Sigma1278b was first isolated in the lab of Marcelle Grenson in the early 1960s, as described in André B (2018) Tribute to Marcelle Grenson (1925-1996), A Pioneer in the Study of Amino Acid Transport in Yeast. Int J Mol Sci 19(4), PMID:29659503, which contains the complete, exact pedigree of Σ1278b from the Grenson lab archives. A short excerpt: "A new, prototrophic reference strain was thus isolated: strain Σ1278b. It was obtained by first crossing the YFa-derived yeast D77 (auxotrophic for uracil and glutamate) with the yeast 1422-11D that was received from the American geneticist Donald C. Hawthorne. The derived haploid strain Σ15d (Σ stands for “segregant”) was then crossed with strain DP1-1B received from Piotr Slonimski, and one of the spores issued from this cross gave rise to Σ1278b." In September 1970, Grenson sent to Gerry Fink a aap/apf1/shr3 mutant isolated from Σ1278b. This strain, which likely diploidized during successive subculturing, was classified as “Fink lab Foreigner strains, F35”. As detailed in the note provided by the Fink lab, collected Nov. 1998 by Cora Styles, analysis twenty years later of this mutant by C. Gimeno and P. Ljungdahl allowed them to discover pseudohyphal growth : Gimeno, C. J., Ljungdahl, P. O., Styles, C. A., & Fink, G. R. (1992). Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell, 68(6), 1077–1090, PMID:1547504. Thanks to Bruno André for contacting SGD directly to share and disseminate this information. Notes: Used in pseudohyphal growth studies. Detailed notes about the sigma strains have been kindly provided by Cora Styles. Granek and Magwene, PLoS Genet. 2010 Jan 22;6(1):e1000823, established that certain lineages of the Sigma1278B background contain a nonsense mutation in RIM15, a G-to-T transversion at position 1216 that converts a Gly codon to an opal stop codon. This rim15 mutation interacts epistatically with mutations in certain other genes to affect colony morphology. The Sigma1278b genome is closely related to S288c, and shares some other genomic regions with W303 [1]. Annotation of the Sigma1278b genome and information about the systematic deletion collection can be found in Dowell et al. (2010).
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
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