Mesoangioblasts MABs cells BioVector NTCC质粒载体菌种细胞基因保藏中心

Mesoangioblasts MABs cells

Mesoangioblasts are blood vessel–associated multipotent mesodermal progenitors that can be isolated from fetal muscle biopsy tissue fragments containing small blood vessels. Since MABs are able to cross the vessel wall and are easily transduced with lentiviral vectors, they have been used in preclinical models of cell therapy for muscular dystrophy. Intra-arterial delivery of either wild-type or genetically corrected MABs morphologically and functionally ameliorated the dystrophic phenotype of mice lacking α-sarcoglycan (Sgca), which model limb girdle muscular dystrophy 2D caused by mutations in the SGCA gene, in mice lacking dysferlin (a model for LGMD2B), and also in mdx mice. In addition, intra-arterial delivery of wild-type postnatal canine MABs resulted in extensive recovery of dystrophin expression and ameliorated pathologic muscle morphology and function in Golden Retriever dogs which model DMD. Similar cells have been isolated from human postnatal skeletal muscle and shown to represent a subset of pericytes and to give rise to dystrophin- positive muscle fibers when transplanted into scid/mdx mice. Moreover, evidence was recently obtained, through cre-lox lineage traces, that pericytes from skeletal muscle contribute to skeletal muscle fiber growth and enter the satellite cell pool, during unperturbed postnatal development of normal mice.

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