Human GPR119/HEK293 Stable Cell Line稳转细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥598685
- 货 号：GPR119/HEK293 Stable Cell Line
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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Human GPR119/HEK293 Stable Cell Line稳转细胞株
Human GPR119/HEK293 Stable Cell Line- Alias GPR119,GPCR2,hGPCR2,MGC119957 Growth Properties Adherent Host Cell HEK293 (CHO and other cell types are also available) Morphology Epithelial Species Human Quality Control Negative for bacteria, yeast, fungi and mycoplasma. Size/Form 2 × 10^6 cells / vial Background GPR119 is a GPCR that is predominately expressed in pancreatic beta cells and enteroendocrine cells in the GI tract in humans. Phospholipids and fatty acid amines are possible endogenous ligands, and oleylethanolamide is one of the more potent ligands known. Agonists of GPR119 elevate cyclic AMP levels in cell models which can potentiate glucose-stimulated insulin secretion. In mice, it has been showed that a GPR119 agonist stimulated the release of both GLP-1 and GIP in wildtype, but not GPR119-deficient animals. GPR119 agonists also improve glycaemic control for mice in vivo, and GLP-1 administration reduces food intake and results in weight loss in humans. Taken together, these data suggest that GPR119 could be an important target for therapeutic management of diabetes and obesity in humans. Using BioVector's proprietary lentiviral vectors, we subclone the target gene into lentivector, generate the lentivirus particles, sequentially infect the cell line HEK293 (other cell types are also available according to your requirements), and select the clones constantly expressing target gene at high level.
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
Human GPR119/HEK293 Stable Cell Line- Alias GPR119,GPCR2,hGPCR2,MGC119957 Growth Properties Adherent Host Cell HEK293 (CHO and other cell types are also available) Morphology Epithelial Species Human Quality Control Negative for bacteria, yeast, fungi and mycoplasma. Size/Form 2 × 10^6 cells / vial Background GPR119 is a GPCR that is predominately expressed in pancreatic beta cells and enteroendocrine cells in the GI tract in humans. Phospholipids and fatty acid amines are possible endogenous ligands, and oleylethanolamide is one of the more potent ligands known. Agonists of GPR119 elevate cyclic AMP levels in cell models which can potentiate glucose-stimulated insulin secretion. In mice, it has been showed that a GPR119 agonist stimulated the release of both GLP-1 and GIP in wildtype, but not GPR119-deficient animals. GPR119 agonists also improve glycaemic control for mice in vivo, and GLP-1 administration reduces food intake and results in weight loss in humans. Taken together, these data suggest that GPR119 could be an important target for therapeutic management of diabetes and obesity in humans. Using BioVector's proprietary lentiviral vectors, we subclone the target gene into lentivector, generate the lentivirus particles, sequentially infect the cell line HEK293 (other cell types are also available according to your requirements), and select the clones constantly expressing target gene at high level.
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
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