INS-1 832/3 Rat Insulinoma Cell Line BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥99865
- 货 号：INS-1 832/3 Rat Insulinoma Cell Line
- 产 地：北京
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- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
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手机：18901268599
地址：北京
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INS-1 832/3 Rat Insulinoma Cell Line
General descriptionGlucose-stimulated insulin secretion (GSIS) is potentiated by pancreatic beta cells and is critical to the physiological control of blood glucose levels. Insulin secretion is impaired in type 2 diabetes, and insight into the mechanisms and regulation of insulin secretion is fundamental to understanding the roles of beta cells in metabolic disease.The rat insulinoma cell line INS-1 is a well-established model for studies of pancreatic islet beta-cell function [1]; however, the GSIS response of INS-1 cells may decrease over time. The INS-1 832/3 cell line is a subclone of INS-1 that was selected for robust GSIS, producing and secreting both rat and human insulin. INS-1 832/3 harbors a human insulin expression cassette allowing for human insulin secretion to be maintained over extended passages with selection [3]. INS-1 832/3 cells are widely used to study the mechanisms of cellular insulin secretion, storage and synthesis. INS-1 832/3 cells may be characterized by granular staining for synaptotagmin, as described for the parental cell line [4]. The INS-1 832/3 cell line exhibits the unique feature of additional insulin secretion in response to natural incretin hormones such as glucagon-like peptide 1 (GLP1), pituitary adenylate cyclase-activating peptide (PACAP), and gastric inhibitory peptide (PIP) [2], making INS-1 832/3 a valuable tool for physiologically relevant investigations of insulin regulation.Source:INS-1 832/3 is a derivative of INS-1 cells originally established from an x-ray induced insulinoma in rat1. The INS-1 832/3 cell line is a subclone of INS-1 that was stably transfected with a CMV promoter-human insulin expression plasmid carrying a geneticin (G418)-resistance marker for selection [3].Cell Line DescriptionCancer CellsApplicationINS-1 832/3 rat insulinoma cell line is a useful model for insulin secretion regulation and pancreatic islet beta-cell function studies.Research CategoryMetabolismResearch Sub CategoryDiabetes
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
General descriptionGlucose-stimulated insulin secretion (GSIS) is potentiated by pancreatic beta cells and is critical to the physiological control of blood glucose levels. Insulin secretion is impaired in type 2 diabetes, and insight into the mechanisms and regulation of insulin secretion is fundamental to understanding the roles of beta cells in metabolic disease.The rat insulinoma cell line INS-1 is a well-established model for studies of pancreatic islet beta-cell function [1]; however, the GSIS response of INS-1 cells may decrease over time. The INS-1 832/3 cell line is a subclone of INS-1 that was selected for robust GSIS, producing and secreting both rat and human insulin. INS-1 832/3 harbors a human insulin expression cassette allowing for human insulin secretion to be maintained over extended passages with selection [3]. INS-1 832/3 cells are widely used to study the mechanisms of cellular insulin secretion, storage and synthesis. INS-1 832/3 cells may be characterized by granular staining for synaptotagmin, as described for the parental cell line [4]. The INS-1 832/3 cell line exhibits the unique feature of additional insulin secretion in response to natural incretin hormones such as glucagon-like peptide 1 (GLP1), pituitary adenylate cyclase-activating peptide (PACAP), and gastric inhibitory peptide (PIP) [2], making INS-1 832/3 a valuable tool for physiologically relevant investigations of insulin regulation.Source:INS-1 832/3 is a derivative of INS-1 cells originally established from an x-ray induced insulinoma in rat1. The INS-1 832/3 cell line is a subclone of INS-1 that was stably transfected with a CMV promoter-human insulin expression plasmid carrying a geneticin (G418)-resistance marker for selection [3].Cell Line DescriptionCancer CellsApplicationINS-1 832/3 rat insulinoma cell line is a useful model for insulin secretion regulation and pancreatic islet beta-cell function studies.Research CategoryMetabolismResearch Sub CategoryDiabetes
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
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