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DG75 cell line人B淋巴细胞系DG-75
Cell line name DG-75 Synonyms D.G.-75; DG 75; DG75 Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. Population: Jewish; Ashkenazi. Characteristics: EBV-negative. Characteristics: Infected by the DG-75 retrovirus, a replication-competent, murine leukemia-related retrovirus. Constitutively produces the virus. Doubling time: 18-20 hours (PubMed=188769); ~40-50 hours (DSMZ). Microsatellite instability: Instable (MSI-high) (PubMed=9583678; PubMed=31068700; Sanger). Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: Proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Pleural effusion. Sequence variations Homozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (PubMed=9583678). Heterozygous for TP53 p.Arg283His (c.848G>A) (ClinVar=VCV000142324) (PubMed=9525742). Genome ancestry Source: PubMed=30894373 Origin % genome African 1.72 Native American 1.16 East Asian, North 0 East Asian, South 1.7 South Asian 7.84 European, North 25.56 European, South 62.01 Disease Burkitt lymphoma (NCIt: C2912) Burkitt lymphoma (ORDO: Orphanet_543) Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606) Sex of cell Male Age at sampling 10Y Category Cancer cell line STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=17254797 Markers: Amelogenin X,Y CSF1PO 9,10,12 (DSMZ) 10 (PubMed=17254797) 10,11,12 (ATCC; Cosmic-CLP) D3S1358 16,17 D5S818 12 D7S820 11,12 (PubMed=17254797) 11.3,12 (DSMZ) 11.3,12,12.3 (ATCC) 12 (Cosmic-CLP) D8S1179 13,15 D13S317 9,11 (PubMed=17254797) 11 (ATCC; Cosmic-CLP; DSMZ) D16S539 11 (PubMed=17254797) 11,12 (Cosmic-CLP; DSMZ) 12 (ATCC) D18S51 11,13 D21S11 27,30 FGA 20,23 TH01 6,7 TPOX 8,11 vWA 16,17,18 (DSMZ) 17,18 (ATCC; PubMed=17254797) 17,18,19 (Cosmic-CLP)
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Cell line name DG-75 Synonyms D.G.-75; DG 75; DG75 Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. Population: Jewish; Ashkenazi. Characteristics: EBV-negative. Characteristics: Infected by the DG-75 retrovirus, a replication-competent, murine leukemia-related retrovirus. Constitutively produces the virus. Doubling time: 18-20 hours (PubMed=188769); ~40-50 hours (DSMZ). Microsatellite instability: Instable (MSI-high) (PubMed=9583678; PubMed=31068700; Sanger). Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: Protein expression by reverse-phase protein arrays. Omics: Proteome analysis by 2D-DE/MS. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Pleural effusion. Sequence variations Homozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (PubMed=9583678). Heterozygous for TP53 p.Arg283His (c.848G>A) (ClinVar=VCV000142324) (PubMed=9525742). Genome ancestry Source: PubMed=30894373 Origin % genome African 1.72 Native American 1.16 East Asian, North 0 East Asian, South 1.7 South Asian 7.84 European, North 25.56 European, South 62.01 Disease Burkitt lymphoma (NCIt: C2912) Burkitt lymphoma (ORDO: Orphanet_543) Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606) Sex of cell Male Age at sampling 10Y Category Cancer cell line STR profile Source(s): ATCC; Cosmic-CLP; DSMZ; PubMed=17254797 Markers: Amelogenin X,Y CSF1PO 9,10,12 (DSMZ) 10 (PubMed=17254797) 10,11,12 (ATCC; Cosmic-CLP) D3S1358 16,17 D5S818 12 D7S820 11,12 (PubMed=17254797) 11.3,12 (DSMZ) 11.3,12,12.3 (ATCC) 12 (Cosmic-CLP) D8S1179 13,15 D13S317 9,11 (PubMed=17254797) 11 (ATCC; Cosmic-CLP; DSMZ) D16S539 11 (PubMed=17254797) 11,12 (Cosmic-CLP; DSMZ) 12 (ATCC) D18S51 11,13 D21S11 27,30 FGA 20,23 TH01 6,7 TPOX 8,11 vWA 16,17,18 (DSMZ) 17,18 (ATCC; PubMed=17254797) 17,18,19 (Cosmic-CLP)
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