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奥马珠单抗Omalizumab (anti-IgE) 242138-07-4

  • 价  格:¥15985
  • 货  号:242138-07-4
  • 产  地:北京
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中文名称:OMALIZUMAB

中文同义词:奥马珠单抗

英文名称:OMALIZUMAB

英文同义词:OMALIZUMAB;Xolair;Omalizumab - buffer solution

产品描述

奥马珠单抗类似物是一种选择性与人IgE结合的重组DNA人源化单克隆抗体,分子量约149kDa,由中国仓鼠卵巢细胞悬浮培养生产。

性质


Name


Biosimilar of Omalizumab

CAS NO.


242138-07-4

Type


Whole antibody

Source


Humanized (from mouse)

Target


IgE Fc region

Clone


Monoclone

Molecular Weight


149 kDa

Formula


C6450H9916N1714O2023S38

Antibody Form


Purified immunoglobulin

Physical Form


Solution

Grade Standard


Medicine Grade

Storage


-70±15℃ for long-term storage, 2-8℃ for short-term storage, away from light.

生物活性

奥马珠单抗Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Omalizumab inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds. When IgE is bound to the receptor, the antigenic epitope on IgE to which omalizumab binds is sterically hindered by the receptor and is not accessible to omalizumab binding, thus averting the anaphylactic effects presumably unavoidable with an ordinary anti-IgE antibody . Furthermore, although the peptide elements on IgE involved in binding to low affinity IgE receptor (FcεRII) on many cell types are different from the peptide elements involved in binding to FcεRI, omalizumab, by steric hindrance, also prevents binding of IgE to FcεRII.
不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

小鼠 大鼠 兔 豚鼠 仓鼠 狗
重量 (kg) 0.02 0.15 1.8 0.4 0.08 10
体表面积 (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km 系数 3 6 12 8 5 20
动物 A (mg/kg) = 动物 B (mg/kg) × 动物 B的Km系数
动物 A的Km系数

例如,依据体表面积折算法,将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量,需要将22.4 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。
储备液配制

以下数据基于产品分子量,对于特殊产品,请参照COA中的储备液配制条件和说明进行操作。
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.0069 mL 0.0345 mL 0.0689 mL
5 mM 0.0014 mL 0.0069 mL 0.0138 mL
10 mM 0.0007 mL 0.0034 mL 0.0069 mL
参考文献

Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases.
Chang TW, et al. Adv Immunol. 2007;93:63-119. PMID: 17383539.

Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders.
Schulman ES. Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 2):S6-11. PMID: 11704611

单抗药物对照品
贝伐单抗,Bevacizumab 纳武单抗,Nivolumab
帕妥珠单抗,Pertuzumab 曲妥珠单抗,Trastuzumab
阿达木单抗,Adalimumab 帕姆单抗,Pembrolizumab
迪诺苏单抗,Denosumab 阿替唑单抗,Atezolizumab
优特克诺单抗,Ustekinumab 维多珠单抗,Vedolizumab
1、33个产品,三种规格:1mg,2mg,5mg;
2、价格优,全现货;
3、科研产品,仅用科研,禁用临床;

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