M14 cell line人黑色素瘤细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

M14 cell line人黑色素瘤细胞株

Cell line name M14
Synonyms M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; Melanoma 14; M-14
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Doubling time: 26.3 hours (NCI-DTP).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: DNA methylation analysis.
Omics: Fluorescence phenotype profiling.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (ClinVar=VCV000013961) (PubMed=12068308; PubMed=17088437; PubMed=19799798; PubMed=29492214).
Heterozygous for CDKN2A c.150+2T>C (IVS1+2T>C); splice donor mutation and c.455insCdel26 (PubMed=19799798; PubMed=29492214).
Heterozygous for TP53 p.Gly266Glu (c.797G>A) (ClinVar=VCV000161516) (PubMed=17088437; PubMed=18277095).
HLA typing Source: PubMed=15748285
Class I
HLA-A A*11:01:01,24:02:01
HLA-B B*15,35
HLA-C C*03:03:01,04
Class II
HLA-DP DPB1*13:01,19:01
HLA-DQ DQB1*03:02,06:03
HLA-DR DRB1*04:05:01,13:01:01

Disease Amelanotic melanoma (NCIt: C3802)
Derived from metastatic site: Subcutaneous; right buttock.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: (BHP 14-9)
Originate from same individual MF14
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Genome ancestry Source: PubMed=30894373

Origin % genome
African 0.64
Native American 0
East Asian, North 0
East Asian, South 1.08
South Asian 0
European, North 67.89
European, South 30.39
STR profile Source(s): Cosmic-CLP; DOI=10.4172/2157-7145.S2-005; PubMed=19372543; PubMed=28940260

Markers:
Amelogenin X
CSF1PO 11
D1S1656 11,12
D2S441 11,14
D2S1338 19,24
D3S1358 14,16
D5S818 11,12
D7S820 8,10
D8S1179 13
D10S1248 14
D12S391 18,19
D13S317 12
D16S539 9,13
D18S51 13,17
D19S433 14,15
D21S11 30
D22S1045 15
FGA 21
SE33 15,22
TH01 6,7
TPOX 8,11
vWA 16,18

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