TAK1基因表达质粒敲除载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

TAK1基因表达质粒敲除载体

RefSeq NM_003188.1, NM_003188.2, NM_003188.3, NP_003179.1 RefSeq Size 2912 RefSeq ORF 1740 Locus ID 6885 Cytogenetics 6q15 Domains pkinase, TyrKc, S_TKc Protein Families Druggable Genome, Protein Kinase Protein Pathways Adherens junction, MAPK signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Wnt signaling pathway MW 64 kDa Gene Summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

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