RCC4 cell line人肾癌细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

RCC4 cell line人肾癌细胞株

Cell line name RCC4
Synonyms RCC-4
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Sequence variations Hemizygous for VHL p.Ser65Trp (c.194C>G) (PubMed=21258414).
Genome ancestry Source: PubMed=30894373
Origin % genome

African 1.89
Native American 0
East Asian, North 3.32
East Asian, South 0
South Asian 0.27
European, North 55.04
European, South 39.47

Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:

(RCC4/empty vector) (RCC4/VHL) (SLR24)

Category Cancer cell line
Publications PubMed=10353251; DOI=10.1038/20459
Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Nature 399:271-275(1999)

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