GM16530 cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

GM16530 cell line细胞株

Cell line name GM16530

Comments Characteristics: Cytoplasmic transfer (cybrid) produced by the fusion of Leigh syndrome enucleated cells GM13740 (CVCL_8A62) with cell line devoid of mitochondrial DNA (rho0) derived from 143B (CVCL_2270).
Disease Leigh disease (NCIt: C84814)
Leigh syndrome (ORDO: Orphanet_506)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2270 (143B)
Parent: CVCL_8A62 (GM13740)
Category Hybrid cell line
Publications

PubMed=8078883; DOI=10.1073/pnas.91.18.8334
Trounce I.A., Neill S., Wallace D.C.
Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.
Proc. Natl. Acad. Sci. U.S.A. 91:8334-8338(1994)

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