WM1553C cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥98635
- 货 号：WM1553C cell line细胞株
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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WM1553C cell line细胞株
BackgroundWM1552C is a non-tumorigenic (RGP) primary human melanoma cell line without metastatic capability. This cell line was established from a subcutaneous tissue in a 72-year-old male with stage III superficial spreading melanoma. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line also expresses PTEN loss of function including mutated and hemizygous PTEN deletion and is wild type for N-RAS, c-KIT, and CDK4. WM1552C cells produce xenograft tumors when injected into immunocompromised mice.SynonymsMelanoma, patient derived tumor, tumor models, skin cancer, xenograftStorage ConditionCells are frozen with 90% FBS/10% DMSO solution at about 1x10^6 cells/ml. Store vial in liquid nitrogen upon arrival.Application NoteThe key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
BackgroundWM1552C is a non-tumorigenic (RGP) primary human melanoma cell line without metastatic capability. This cell line was established from a subcutaneous tissue in a 72-year-old male with stage III superficial spreading melanoma. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line also expresses PTEN loss of function including mutated and hemizygous PTEN deletion and is wild type for N-RAS, c-KIT, and CDK4. WM1552C cells produce xenograft tumors when injected into immunocompromised mice.SynonymsMelanoma, patient derived tumor, tumor models, skin cancer, xenograftStorage ConditionCells are frozen with 90% FBS/10% DMSO solution at about 1x10^6 cells/ml. Store vial in liquid nitrogen upon arrival.Application NoteThe key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Supplier来源:BioVector NTCC Inc.
TEL电话:+86-010-53513060
Website网址: http://www.biovector.net
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