LOX-IMVI cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

LOX-IMVI cell line细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

Cell line name LOX-IMVI
Synonyms LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: NCI-60 cancer cell line panel.
Doubling time: 19.9 hours (PubMed=22628656); 20.5 hours (NCI-DTP).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Fluorescence phenotype profiling.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: LOXMVII; In Cosmic 1044264.
Misspelling: LOXIN-VI; In PubMed=12068308, Cosmic 687446 and Cosmic 897466.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (PubMed=12068308; PubMed=17088437; CCLE; Cosmic-CLP).
TERT c.228C>T (-124C>T); in promoter (PubMed=31068700).
Has no TP53 mutation (CCLE; Cosmic-CLP).
HLA typing Source: PubMed=15748285
Class I
HLA-A A*11:01:01,29:02
HLA-B B*07:02:01,44:03:01
HLA-C C*07:02:01,16:01
Class II
HLA-DP DPB1*04:01,11:01:01
HLA-DQ DQB1*02:02,06:02
HLA-DR DRB1*07:01,15:01:01

Genome ancestry Source: PubMed=30894373
Origin % genome

African 1.11
Native American 0
East Asian, North 2.55
East Asian, South 0
South Asian 0
European, North 67.19
European, South 29.14

Disease Amelanotic melanoma (NCIt: C3802)
Derived from metastatic site: Axillary lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=19372543; PubMed=25877200

Markers:
Amelogenin X
CSF1PO 10,12
D2S1338 18,24
D3S1358 14,15
D5S818 11,13
D7S820 9,11
D8S1179 11,13
D13S317 11
D16S539 10,12
D18S51 15,18
D19S433 14.2
D21S11 28,31
FGA 22
Penta D 9,11
Penta E 5,7
TH01 7,9.3
TPOX 9,11
vWA 14,17

Publications PubMed=3346110; DOI=10.1002/ijc.2910410322
Fodstad O., Aamdal S., McMenamin M.G., Nesland J.M., Pihl A.
A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX.
Int. J. Cancer 41:442-449(1988)
Malignant melanoma is highly treatable when diagnosed early, but can spread rapidly if undetected, resulting in the highest mortality among skin cancer types. Lymph nodes and lungs are the most common sites of melanoma metastases,1 and because of the poor prognosis and limited efficacy of current treatments, metastatic melanoma has generated intense interest as a target for therapeutic intervention. The LOX-IMVI human melanoma cell line is widely used as an in vitro model system to study tumor metastasis and to test for chemosensitivity to potential anti-cancer compounds. LOXIMVI cells exhibit a tendency to form lung metastases in nude mice independent of the inoculation site, and mortality of experimental animals is observed within 3-5 weeks of injection. LOX-IMVI cells are genetically characterized by lack of the Y chromosome and trisomy 7, and are heterozygous for the BRAF V600E melanoma driver mutation. LOX-IMVI cells are amelanotic and express the human melanoma marker GD3 ganglioside, a factor in metastatic potential of malignant melanoma.5 The LOX-IMVI human melanoma cell line is an excellent proven model for probing mechanisms of metastasis and for evaluation of chemotherapies.

Source
The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma.


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