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BMP4基因表达/敲除干扰/荧光/慢病毒/基因编辑质粒cDNA BioVector NTCC质粒载体菌种细胞基因保藏中心

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BMP4基因表达/敲除干扰/荧光/慢病毒/基因编辑质粒cDNA BioVector NTCC质粒载体菌种细胞基因保藏中心
Human bone morphogenetic protein 4 (BMP4),
RefSeq: NM_001202.2, NP_001193 RefSeq Size: 1999 RefSeq ORF: 1227 Synonyms : BMP2B; BMP2B1; MCOPS6; OFC11; ZYME LocusID: 652 Cytogenetic: 14q22.2 Domains: TGFb_propeptide, TGFB Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
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