PDE6B基因表达质粒-慢病毒质粒-基因沉默敲除质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心

PDE6B基因表达质粒-慢病毒质粒-基因沉默敲除质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心
Human phosphodiesterase 6B, cGMP-specific, rod, beta (PDE6B)
RefSeq: NM_000283.2, NP_000274
RefSeq Size: 3283 RefSeq ORF: 2565
Synonyms : CSNB3; CSNBAD2; PDEB; rd1; RP40
LocusID: 5158 Cytogenetic: 4p16.3 Domains: PDEase, GAF, HDc
Summary: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene
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