pcDNA-CD22 v1-flag基因表达质粒载体 BioVector NTCC质粒载体菌种细胞基因保藏中心
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pcDNA-CD22 v1-flag基因表达质粒载体 BioVector NTCC质粒载体菌种细胞基因保藏中心
RefSeq NM_001771.1, NM_001771.2, NM_001771.3, NP_001762.2
RefSeq Size 3300
RefSeq ORF 2544
Locus ID 933
Cytogenetics 19q13.12
Domains ig, IGc2, IG
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway, Cell adhesion molecules (CAMs), Hematopoietic cell lineage
MW 95.8 kDa
Gene Summary Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProtKB/Swiss-Prot Function]
【Supplier来源】BioVector NTCC Inc.
TEL：+86-010-53513060
【Website网址】 http://www.biovector.net
RefSeq NM_001771.1, NM_001771.2, NM_001771.3, NP_001762.2
RefSeq Size 3300
RefSeq ORF 2544
Locus ID 933
Cytogenetics 19q13.12
Domains ig, IGc2, IG
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway, Cell adhesion molecules (CAMs), Hematopoietic cell lineage
MW 95.8 kDa
Gene Summary Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProtKB/Swiss-Prot Function]
【Supplier来源】BioVector NTCC Inc.
TEL：+86-010-53513060
【Website网址】 http://www.biovector.net
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