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Streptomyces sp. NRRL S-31 strain菌株菌种 BioVector NTCC质粒载体菌种细胞基因保藏中心

  • 价  格:¥99865
  • 货  号:Streptomyces sp. NRRL S-31 strain菌株菌种
  • 产  地:北京
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Streptomyces sp. NRRL S-31 strain菌株菌种 BioVector NTCC质粒载体菌种细胞基因保藏中心
A new oxygenase component of SMO, named StStyA, has been identified from the genome of Streptomyces sp. NRRL S-31, which appears to be the first natural SMO that catalyzes the production of (R)-styrene oxide. The artificial two-component SMO based on StStyA and a known reductase component successfully catalyzes the bio-epoxidation of five aromatic alkenes with consistent (R)-selectivity, and the enantiomeric excess of the products generated ranged from 91% in the case of styrene to >99% in the case of 4-vinyl-2,3-dihydrobenzofuran. This work offers a new approach for the asymmetric epoxidation of (R)-styrene oxide and analogues, and would provide insights into the source of selectivity for the future study of SMOs.


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