Human YTH domain containing 2 (YTHDC2)基因表达质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心

Human YTH domain containing 2 (YTHDC2)基因表达质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心
Human YTH domain containing 2 (YTHDC2)
RefSeq: NM_022828.2, NP_073739
RefSeq Size: 6301 RefSeq ORF: 4293
Synonyms : CAHL; CAHL
LocusID: 64848 Cytogenetic: 5q22.2 Domains: YTH, HA2
Summary: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.
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