ANGPTL4基因表达质粒载体pcDNA3.1-ANGPTL4 BioVector NTCC质粒载体菌种细胞基因保藏中心

ANGPTL4基因表达质粒载体pcDNA3.1-ANGPTL4 BioVector NTCC质粒载体菌种细胞基因保藏中心
RefSeq: NM_139314.1, NP_647475
RefSeq Size: 1967 RefSeq ORF: 1221
Synonyms : ANGPTL2; ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158; TGQTL; UNQ171
LocusID: 51129 Cytogenetic: 19p13.2
Summary: This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4
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