CD8+ Tregs cell line细胞株细胞系 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥49865
- 货 号：CD8+ Tregs cell line细胞株细胞系
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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CD8+ Tregs cell line细胞株细胞系 BioVector NTCC质粒载体菌种细胞基因保藏中心
CD8+ regulatory T cells (CD8+ Tregs), which possess important immunosuppressive functions, are able to effectively block the overreacting immune response and maintain the body's immune homeostasis. In recent years, studies have identified a small set of special CD8+ Tregs that can recognize major histocompatibility complex class Ib molecules, more specifically Qa-1 in mice and HLA-E in humans, and target the self-reactive CD4+ T ce lls. These findings have generated broad implications in the scientific community and attracted general interest to CD8+ Tregs.
In the process of thymic negative selection, only T cell clones with high affinity to autologous antigens are removed. Therefore, certain T cells with low affinity to autologous antigens are leaked to the peripheral immune system. Under certain conditions, they may be activated and result in autoimmune diseases. Therefore, this process is monitored by a series of peripheral immune tolerance mechanisms, including Tregs with immunosuppressive effects, namely CD4+and CD8+ Tregs.
To date, there is no reliable surface marker that is able to distinguish CD8+ Tregs from ordinary CD8+ T cells. In different experimental systems, CD8+ Treg surface molecules have been demonstrated to differ. For instance, in an experimental autoimmune encephalomyelitis (EAE) model, CD8+CD28− Tregs demonstrated an inhibitory effect on the secretion of interferon (IFN)-γ by myelin oligodendrocyte glycoprotein-specific CD4+ T cells through cell contact inhibition.
CD8+ Tregs in humans are predominantly CD8+CD28− Tregs; however, two CD8+ Tregs subgroups can be produced by induction in vitro, namely CD8+CD28+ and CD8+CD28− Tregs. Different types of CD8+ Treg subsets can function by secreting various inhibitory cytokines and chemokines, including IL-10, transforming growth factor (TGF)-β, IL-16, IFN-γ and chemokine (C-C motif) ligand 4.
CD8+ Tregs have been reported to inhibit autoimmune diseases, to potentially originate from the thymus, to negatively regulate activated T cells, to supervise the immune tolerance and to be associated with the management of autoimmune diseases.
【Supplier来源】BioVector NTCC Inc.
TEL：+86-010-53513060
【Website网址】 http://www.biovector.net
CD8+ regulatory T cells (CD8+ Tregs), which possess important immunosuppressive functions, are able to effectively block the overreacting immune response and maintain the body's immune homeostasis. In recent years, studies have identified a small set of special CD8+ Tregs that can recognize major histocompatibility complex class Ib molecules, more specifically Qa-1 in mice and HLA-E in humans, and target the self-reactive CD4+ T ce lls. These findings have generated broad implications in the scientific community and attracted general interest to CD8+ Tregs.
In the process of thymic negative selection, only T cell clones with high affinity to autologous antigens are removed. Therefore, certain T cells with low affinity to autologous antigens are leaked to the peripheral immune system. Under certain conditions, they may be activated and result in autoimmune diseases. Therefore, this process is monitored by a series of peripheral immune tolerance mechanisms, including Tregs with immunosuppressive effects, namely CD4+and CD8+ Tregs.
To date, there is no reliable surface marker that is able to distinguish CD8+ Tregs from ordinary CD8+ T cells. In different experimental systems, CD8+ Treg surface molecules have been demonstrated to differ. For instance, in an experimental autoimmune encephalomyelitis (EAE) model, CD8+CD28− Tregs demonstrated an inhibitory effect on the secretion of interferon (IFN)-γ by myelin oligodendrocyte glycoprotein-specific CD4+ T cells through cell contact inhibition.
CD8+ Tregs in humans are predominantly CD8+CD28− Tregs; however, two CD8+ Tregs subgroups can be produced by induction in vitro, namely CD8+CD28+ and CD8+CD28− Tregs. Different types of CD8+ Treg subsets can function by secreting various inhibitory cytokines and chemokines, including IL-10, transforming growth factor (TGF)-β, IL-16, IFN-γ and chemokine (C-C motif) ligand 4.
CD8+ Tregs have been reported to inhibit autoimmune diseases, to potentially originate from the thymus, to negatively regulate activated T cells, to supervise the immune tolerance and to be associated with the management of autoimmune diseases.
【Supplier来源】BioVector NTCC Inc.
TEL：+86-010-53513060
【Website网址】 http://www.biovector.net
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