CDC42, (NM_001791)，LOC643751基因表达质粒cDNA全长ORF克隆启动子报告质粒/腺病毒慢病毒逆病毒RNAi载体

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货　　号：Biovector226145
产　　地：北京

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Human cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 1

Reference Data
RefSeq	NM_001791.4
RefSeq Size	2183 bp
RefSeq ORF	576 bp
Locus ID	998
Domains	ras, RAS, RHO, RAB
Protein Families	Druggable Genome
Protein Pathways	Adherens junction, Axon guidance, Chemokine signaling pathway, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Fc gamma R-mediated phagocytosis, Focal adhesion, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Tight junction, VEGF signaling pathway
MW	21.1 kDa
Gene Summary	The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.

该基因cDNA，全长ORF及其克隆质粒/表达质粒/启动子报告质粒/腺病毒慢病毒逆病毒RNAi载体由Biovector现货供应

包括如下（基因名称以 “Gene”代替）：真核表达质粒pCMV-GENE，pCMV-GENE-Flag,pcDNA3.1-GENE,pCMV-His-GENE,pCMV-Myc-GENE,pCMV-GST-Gene,pCMV-HA-Gene,pCMV-SPORT6-GENE,真核荧光表达质粒pCMV-GENE-EGFP，pEGFP-GENE,pCMV-mCherry-GENE,pCMV-ECFP-GENE,pCMV-EYFP-GENE,pCMV-Luc-ORF,真核表达载体特点:携带CMV启动子，可在真核细胞进行表达；带T7启动子，可转化大肠杆菌，进行原核蛋白表达；有融合N、C端EGFP, Flag, His, myc, HA等标签的质粒，可用于蛋白纯化、检测及跟踪；含有Neomycin, puromycin等筛选标记，可用于构建稳定细胞株。慢病毒载体pLenti-CMV-GENE-puro,pLenti-CMV-GENE-V5,原核表达质粒pET-GENE,pTac-GENE-GST,pTac-GENE-MBP,pT7-GENE-HisSUMO，pBAD-GENE,pQE-GENE,pGEX-GENE-GST,酵母表达质粒pGAL1-GENE,pADH-GENE-GAL4AD,pADH-GENE-GAL4BD,昆虫细胞表达载体pPH-His-GENE,Wheet Germ Cell Free（麦胚无细胞体系）表达质粒pT7-His-GENE,Gateway兼容的克隆质粒pDONR223-GENE，pENTR-GENE,克隆质粒pOTB7-GENE, pBluescriptR-GENE，pCMV-SPORT6-GENE,全长转录本 cDNA 克隆 (含 5' 和 3' UTRs)，基因沉默RNAi(shRNA,siRNA,miRNA)载体pSilencer-Gene,pSIREN-reteoQ-Gene,启动子报告质粒pGene Promoter-GLuc, pGene Promoter-GLuc-CMV-SEAP,pGene Promoter-EGFP,pGene Promoter-mCherry,启动子报告慢病毒质粒pLenti- Promoter-GLuc,等；以上现货当日可发送;另可根据您的需要选择载体骨架定制表达质粒,一周左右完成交付。