EML4-ALK特定位点突变质粒（T1151Sins突变） BioVector NTCC质粒载体菌种细胞基因保藏中心
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- 货 号：EML4-ALK特定位点突变质粒（T1151Sins突变）
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地址：北京
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EML4-ALK特定位点突变质粒（T1151Sins突变） BioVector NTCC质粒载体菌种细胞基因保藏中心 EML4.Human echinoderm microtubule associated protein like ,
RefSeq: NM_019063.2, NP_061936 RefSeq Size: RefSeq ORF: 5565 Synonyms : C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120 LocusID: 27436 Cytogenetic: 2p21 Domains: WD40, HELP Summary: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
Human anaplastic lymphoma receptor tyrosine kinase (ALK)
RefSeq: NM_004304.3, NP_004295 RefSeq Size: 6222 RefSeq ORF: 4863 Synonyms : CD246; NBLST3 LocusID: 238 Cytogenetic: 2p23.2-p23.1 Summary: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心 电话：+86-010-53513060 网址：www.biovector.net [Supplier来源] http://www.biovector.net
RefSeq: NM_019063.2, NP_061936 RefSeq Size: RefSeq ORF: 5565 Synonyms : C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120 LocusID: 27436 Cytogenetic: 2p21 Domains: WD40, HELP Summary: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
Human anaplastic lymphoma receptor tyrosine kinase (ALK)
RefSeq: NM_004304.3, NP_004295 RefSeq Size: 6222 RefSeq ORF: 4863 Synonyms : CD246; NBLST3 LocusID: 238 Cytogenetic: 2p23.2-p23.1 Summary: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心 电话：+86-010-53513060 网址：www.biovector.net [Supplier来源] http://www.biovector.net
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